Immunity, by William E. Paul
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Immunity, by William E. Paul
Ebook PDF Immunity, by William E. Paul
This significant book conveys Dr. William E. Paul’s enduring enthusiasm for the field of immunology, the incredible accomplishments of the past half-century, and the future’s untapped promises.
The immune system has incredible power to protect us from the ravages of infection by killing disease-causing microbes or eliminating them from the body. Boosted by vaccines, it can protect us individually and as a "herd" from diseases such as measles. As Dr. Paul explains, however, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the clinical agonies of AIDS and other immunodeficiency diseases.
Packed with illustrations, stories from Dr. Paul’s distinguished career, and compelling narratives of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system protects and harms us. From the tale of how smallpox was overcome to the lessons of the Ebola epidemic to the utility of vaccines and the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome.
Immunity, by William E. Paul- Amazon Sales Rank: #211612 in eBooks
- Published on: 2015-10-01
- Released on: 2015-10-01
- Format: Kindle eBook
Review
A treasure trove of information, this wonderful book should broadly appeal to anyone interested in human health and disease. There is no competing volume that covers such breadth of immunology at this personal level. A tour de force.
(Daniel M. Davis, University of Manchester, author of The Compatibility Gene: How Our Bodies Fight Disease, Attract Others, and Define Our Selves)Dr. Paul has lived the modern history of basic and applied immunology. His warm, down-to-earth style and deep insight into biology lead the reader on a fascinating journey in understanding these diverse processes from the vantage point of a discovery scientist.
(Hyam Levitsky, MD, Johns Hopkins University School of Medicine)Immunity is at once an informative history of immunology with numerous personal asides and a brilliant introduction to the wonders of this key field of medical science. The novice can learn immunology from this book while the professional will appreciate Dr. Paul’s role in the history and enjoy his erudition and judgment.
(David Baltimore, California Institute of Technology, Nobel Prize Winner in Physiology or Medicine, 1975)Bill Paul recounts in a clear fashion the ideas, experiments and insights that have led us to our present day understanding of immunity. Along the way we encounter new viruses, autoimmunity and the latest insights in cancer immunotherapy.
(Arnold Levine, PhD, Professor Emeritus, Institute for Advanced Study, Princeton N.J.)An excellent overview of what science knows about immunology today.
(Harriet Hall Science-Based Medicine)Written by a prominent researcher and scholar who not only followed the history of immunology but also participated in its creation, Immunity could be considered as an excellent summary of the classical, pre-systemic, immunological era.
(Metascience)From the Back Cover This new collection of 12 articles form Scientific American illustrates key facets of the immune system, providing a striking picture of our defense against infectious agents.
About the Author
William E. Paul, MD, is the chief of the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. He received his medical degree from the State University of New York Downstate Medical Center. He is a past president of the American Association of Immunologists and the American Society for Clinical Investigation, a member of the National Academy of Sciences and its Institute of Medicine, and a Fellow of the American Academy of Arts and Sciences.
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Most helpful customer reviews
3 of 3 people found the following review helpful. Fantastic Scientific Read By Debbie Cole I was expecting something very different from Immunity. Instead of an autobiography concerning the life and career of one of the world's most eminent immunologist, I got a mix of dry textbook and autobiography. I don't know if I consider this a good or bad thing, but I definitely think this book is written for a specific audience and it's not the lay man.William E Paul, a prominent member at the National Institute of Health has written plenty of academic texts on immunology, held roles as president of American Association of Immunologists and the American Society for Clinical Investigation, a director of NIH's AIDs research division and has been an editor of the Annual Review of Immunology volumes 1 through 30. It's not surprising that during his career he has met plenty of medical rock stars and contributed heavily in modern immunology research. I can't imagine a better person to write an novel on immunity geared towards doctors without a PhD in Immunology.The main focus of Immunity seems to be on basics of the human immune system, leaps in immunology research both past and present and the changing environment of immunology in the face of funding changes throughout the decades: The success rate (the number of grant applications funded divided by the number submitted) has dropped from 30 percent in 2003 to 19 percent in 2012. Effectively that means that many talented individuals, particularly younger scientists, will fail to obtain research support and may leave science, cutting off a future generation.Immunity took me a few months to read, often with breaks between chapters because I required plenty of research on the basics of Immunology before I could continue. Unfortunately, while William Paul attempts to explain the basics of the study of human immunity, I found it difficult to understand some of the more technical discussions without scouring the internet for discussions on items such as T Cells, cytokines, Th2 and lymphocytes. I particularly enjoyed the small section on jawless vertebrates and adaptive immune systems. I actually learned plenty of really fantastic information that may even lead to a deer understanding of other scientific literature.Fortunately, thanks to William E Paul, I understand quite a bit more about the human immune system and medical science as a whole since reading this autobiography/textbook. I discovered new knowledge, researched new material and learned plenty about the ever changing medical research environment.Do I recommend Immunity? Of course, but only to those wanting an intense read that often requires time for thought. Immunity is not an armchair read. It is not meant to be devoured in one sitting or a few, but in long months of reflection and self-education. Well, that is unless you are already a medical student or immunologist!This book would appeal to readers who are already well educated in medical terminology, lovers of medical science or those who are interested in a very dense novel. I wouldn't suggest this book if you want something basic or instructive on the very basics of immunology. A definite page turner with history, personal anecdotes and plenty of science to keep a reader happy.
3 of 3 people found the following review helpful. Excellent look at immunology By Steve G I received this book for free in exchange for an honest review. Author William E. Paul crafted a great book about the immune system, how it evolved and its role in health and disease. The book is up-to-date and gives the author’s view of what is to come. I also liked the personal stories that Paul told and the biographical information he provided on several important immunologists. Paul is also very specific when stating an opinion, that it is an opinion. This is not necessarily a beginner’s book; a background in biology will be helpful when digesting all the information in the book. Yet for those who have the background, this is a great book that I found hard to put down. I strongly recommend it for anyone interested in biology and for people who want real information on immunology and not the stuff that frequently appears on the internet.
0 of 0 people found the following review helpful. Very readable book about the immune system By A customer Immunity by William E. Paul, MD is a very readable book about how our body’s immune system works to keep us healthy. While I selected this book in hopes of learning more about neutropenia, the book didn’t help me much with that. I did learn more about how neutrophils and how they operate. Some of the topics included in Paul’s book include:*Tracing an immune response*Vaccines and Serum Therapy*What is Tolerance?*CD8 T Cells: Killer cells and friends*The Microbiome and Innate immunity*How the immune system causes Rheumatoid arthritis and Lupus*Allergy and asthmaRecommend.Review written after downloading a galley from Edelweiss.
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